| 03/05/2022 | Brewers | A's | 9:30AM - 12:00PM | Ken Mercer Sports Park / LL-1 | |
| 03/05/2022 | Cubs | Giants | 12:00PM - 2:30PM | Ken Mercer Sports Park / LL-1 | |
| 03/05/2022 | Red Sox | Pirates | 2:30PM - 5:00PM | Ken Mercer Sports Park / LL-1 | |
| 03/05/2022 | Tigers | Reds | 3:00PM - 5:30PM | Ken Mercer Sports Park / LL-2 | |
| 03/09/2022 | A's | Pirates | 5:00PM - 7:30PM | Ken Mercer Sports Park / LL-1 | |
| 03/09/2022 | Red Sox | Brewers | 5:00PM - 7:30PM | Ken Mercer Sports Park / LL-2 | |
| 03/09/2022 | Reds | Cubs | 5:00PM - 7:30PM | Ken Mercer Sports Park / LL-4 | |
| 03/09/2022 | Giants | Tigers | 5:00PM - 7:30PM | Ken Mercer Sports Park / LL-10 | |
| 03/12/2022 | A's | Cubs | 9:30AM - 12:00PM | Ken Mercer Sports Park / LL-1 | |
| 03/12/2022 | Pirates | Reds | 2:30PM - 5:00PM | Ken Mercer Sports Park / LL-1 | |
| 03/12/2022 | Tigers | Red Sox | 3:00PM - 5:30PM | Ken Mercer Sports Park / LL-2 | |
| 03/12/2022 | Giants | Brewers | 3:00PM - 5:30PM | Ken Mercer Sports Park / LL-4 | Rescheduled |
| 03/16/2022 | Red Sox | A's | 5:00PM - 7:30PM | Ken Mercer Sports Park / LL-1 | |
| 03/16/2022 | Brewers | Reds | 5:00PM - 7:30PM | Ken Mercer Sports Park / LL-2 | |
| 03/16/2022 | Cubs | Tigers | 5:00PM - 7:30PM | Ken Mercer Sports Park / LL-4 | |
| 03/16/2022 | Pirates | Giants | 5:00PM - 7:30PM | Ken Mercer Sports Park / LL-10 | |
| 03/19/2022 | Giants | A's | 9:30AM - 12:00PM | Ken Mercer Sports Park / LL-1 | |
| 03/19/2022 | Brewers | Cubs | 12:00PM - 2:30PM | Ken Mercer Sports Park / LL-1 | |
| 03/19/2022 | Tigers | Pirates | 2:30PM - 5:00PM | Ken Mercer Sports Park / LL-1 | |
| 03/19/2022 | Red Sox | Reds | 3:00PM - 5:30PM | Ken Mercer Sports Park / LL-2 | |
| 03/23/2022 | A's | Reds | 5:00PM - 7:30PM | Ken Mercer Sports Park / LL-1 | |
| 03/23/2022 | Tigers | Brewers | 5:00PM - 7:30PM | Ken Mercer Sports Park / LL-2 | |
| 03/23/2022 | Pirates | Cubs | 5:00PM - 7:30PM | Ken Mercer Sports Park / LL-4 | |
| 03/23/2022 | Giants | Red Sox | 5:00PM - 7:30PM | Ken Mercer Sports Park / LL-10 | |
| 03/26/2022 | Tigers | A's | 9:30AM - 12:00PM | Ken Mercer Sports Park / LL-1 | |
| 03/26/2022 | Brewers | Pirates | 12:00PM - 2:30PM | Ken Mercer Sports Park / LL-1 | |
| 03/26/2022 | Cubs | Red Sox | 2:30PM - 5:00PM | Ken Mercer Sports Park / LL-1 | |
| 03/26/2022 | Reds | Giants | 3:00PM - 5:30PM | Ken Mercer Sports Park / LL-2 | |
| 03/30/2022 | A's | Brewers | 5:00PM - 7:30PM | Ken Mercer Sports Park / LL-1 | |
| 03/30/2022 | Giants | Cubs | 5:00PM - 7:30PM | Ken Mercer Sports Park / LL-2 | |
| 03/30/2022 | Pirates | Red Sox | 5:00PM - 7:30PM | Ken Mercer Sports Park / LL-4 | |
| 03/30/2022 | Reds | Tigers | 5:00PM - 7:30PM | Ken Mercer Sports Park / LL-10 | |
| 04/13/2022 | Brewers | Red Sox | 5:30PM - 8:00PM | Ken Mercer Sports Park / LL-2 | |
| 04/13/2022 | Pirates | A's | 5:30PM - 8:00PM | Ken Mercer Sports Park / LL-3 | |
| 04/13/2022 | Cubs | Reds | 5:30PM - 8:00PM | Ken Mercer Sports Park / LL-4 | |
| 04/13/2022 | Tigers | Giants | 5:30PM - 8:00PM | Ken Mercer Sports Park / LL-10 | |
| 04/20/2022 | Cubs | A's | 5:30PM - 8:00PM | Ken Mercer Sports Park / LL-1 | |
| 04/20/2022 | Brewers | Giants | 5:30PM - 8:00PM | Ken Mercer Sports Park / LL-2 | |
| 04/20/2022 | Reds | Pirates | 5:30PM - 8:00PM | Ken Mercer Sports Park / LL-4 | |
| 04/20/2022 | Red Sox | Tigers | 5:30PM - 8:00PM | Ken Mercer Sports Park / LL-10 | |
| 04/23/2022 | A's | Red Sox | 9:30AM - 12:00PM | Ken Mercer Sports Park / LL-1 | |
| 04/23/2022 | Reds | Brewers | 12:00PM - 2:30PM | Ken Mercer Sports Park / LL-1 | |
| 04/23/2022 | Tigers | Cubs | 2:30PM - 5:00PM | Ken Mercer Sports Park / LL-1 | |
| 04/23/2022 | Giants | Pirates | 3:00PM - 5:30PM | Ken Mercer Sports Park / LL-2 | |
| 04/27/2022 | Reds | Red Sox | 5:30PM - 8:00PM | Ken Mercer Sports Park / LL-6 | Rescheduled |
| 04/27/2022 | A's | Giants | 5:30PM - 8:00PM | Ken Mercer Sports Park / LL-1 | |
| 04/27/2022 | Cubs | Brewers | 5:30PM - 8:00PM | Ken Mercer Sports Park / LL-2 | |
| 04/27/2022 | Pirates | Tigers | 5:30PM - 8:00PM | Ken Mercer Sports Park / LL-4 | |
| 04/30/2022 | Reds | A's | 9:30AM - 12:00PM | Ken Mercer Sports Park / LL-1 | |
| 04/30/2022 | Brewers | Tigers | 12:00PM - 2:30PM | Ken Mercer Sports Park / LL-1 | |
| 04/30/2022 | Cubs | Pirates | 2:30PM - 5:00PM | Ken Mercer Sports Park / LL-1 | |
| 04/30/2022 | Red Sox | Giants | 3:00PM - 5:30PM | Ken Mercer Sports Park / LL-2 | |
| 05/04/2022 | A's | Tigers | 5:30PM - 8:00PM | Ken Mercer Sports Park / LL-1 | |
| 05/04/2022 | Pirates | Brewers | 5:30PM - 8:00PM | Ken Mercer Sports Park / LL-2 | |
| 05/04/2022 | Giants | Reds | 5:30PM - 8:00PM | Ken Mercer Sports Park / LL-3 | Rescheduled |
| 05/04/2022 | Red Sox | Cubs | 5:30PM - 8:00PM | Ken Mercer Sports Park / LL-4 | |